Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1142394

Funding Status
Closed

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Funded Activity Summary

We have generated considerable evidence for a role for tissue ferritin as a mediator of inflammation associated with liver fibrosis (scarring) These highly novel and innovative studies will assist in identifying pathways involved in the proinflammatory phenotype of hepatic stellate cells (scar-forming cells in the liver) in chronic liver disease and thus will greatly aid in understanding how liver scarring occurs in chronic liver disease.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $783,612.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ferritin | haemochromatosis | hepatic fibrosis | hepatic stellate cells | liver disease