Characterisation of proteins involved in biomineralisation processes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/114202

Funding Status
Closed

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Funded Activity Summary

This project involves the study of two proteins that associate with calcium and phosphate. Phosphophoryn is found in teeth and is responsible for the development of dentine in teeth. Osteopontin is a multi-functional protein found in a variety of tissues as well as in bone and in milk. Its functions in bone and milk are unknown although it is believed to be involved in bone remodelling. This project involves characterisation of these two proteins and their interactions with calcium phosphate mineral using a variety of techniques. The outcome will be an improved understanding of the design principles used by nature to engineer teeth and bone. The significance is the potential development of biocompatible apatite-based biomaterials for both tooth and bone.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $234,175.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical physiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Biomineralisation | Bone and tooth abnormalities | Bone and tooth biomaterials | Bone and tooth development | Bone and tooth regeneration | Calcium phosphate biology | Phosphoprotein | Protein conformation | Structure - function relationship

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