Neural control of cardiac muscle contractility.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/114190

Funding Status
Closed

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Funded Activity Summary

Although the heart contracts spontaneously, the rate and force with which it beats may be modified by the autonomic nervous system. That is, the rate and force of heart muscle contraction may be increased or decreased by the activation of two different sets of nerves. This project will determine how the autonomic nervous system modifies the strength of heart muscle contraction. It will involve the measurement of changes in contractile force, electrical activity and calcium levels within cardiac cells during muscle contraction. The effects of excitatory and inhibitory nerve stimulation on these three parameters will be examined. Results of this study will improve our understanding of how the contraction of heart muscle is controlled and provide an insight into the treatment of heart disease.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2000

Funding Scheme: NHMRC Project Grants

Funding Amount: $63,543.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Calcium | Cardiomyopathy | Cardiotonic agents | Heart | Heart disease | Low cardiac output | Muscle contraction | Parasympathetic nervous system | Sympathetic nervous system

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