The role of tenascin-C in bone and joint pathology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/114140

Funding Status
Closed

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Funded Activity Summary

Many diseases of bones (e.g.osteoporosis) and joints (e.g. arthritis) result from the abnormal function of cells in these tissues. Factors regulating cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. Tenascin-C is a protein produced by bone and joint cells. The role of tenascin-C in the function of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts) will be investigated. We will investigate whether tenascin-C is required for the bone loss that occurs in female mice when oestrogen is not present. We will also determine the role played by tenascin-C in development and recovery from arthritis. This study will contribute to the understanding of how bone and joint cells function in health and disease.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $215,773.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Rheumatology And Arthritis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chondrocyte | extracellular matrix | fracture repair | osteoarthritis | osteoblast | osteoclast | osteoporosis | rheumatoid arthritis | tenascin-C

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