Deregulation of DNA hydroxymethylases Tet1/ Tet2 compromises skeletal integrity during ageing and bone disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1141361

Funding Status
Closed

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Funded Activity Summary

Epigenetic modifications of DNA and associated proteins regulate gene expression. A greater understanding of the molecular pathways and associated epigenetic changes that regulate bone cell commitment under normal and pathological conditions will help enhance our ability to diagnose and treat disorders/ diseases that effect skeletal tissues through the pharmacological manipulation of epigenetic modifiers and their gene targets.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $850,229.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

epigenetics | musculoskeletal | musculoskeletal disorders | osteoporosis | skeletal disease

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