Functional relationships of gastrin and its regulators in the developing and diseased gastrointestinal tracts

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/114123

Funding Status
Closed

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Funded Activity Summary

Gastrin is a hormone from the stomach which aids digestion by stimulating acid secretion. However too much acid can cause ulcers of the gastrointestinal tract. Gastrin also stimulates growth of the lining of the stomach and intestines. This growth promoting effect is important for the development of the gastrointestinal tract before birth and may also be involved in a number of cancers especially colon cancer. Several different forms of gastrin are made by endocrine cells of the stomach and by cancers of the colon. It seems that the different types of gastrins have different effects and act through distinct receptors. The production and effects of gastrin are mediated in part by the local factor histamine and modified by the hormone somatostatin. The amount, type and activity of gastrin, and the interactions with histamine and somatostatin, will be measured in foetal and newborn animals, and people with or at risk of developing colon cancer.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $607,832.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sport and exercise nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

colon cancer | duodenal ulcers | gastric secretion | gastrin | histamine | neonatal nutrition | peptide processing | somatostatin

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