Resolving and targeting the complex molecular mechanisms underlying GPCR signalling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1141034

Funding Status
Closed

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Funded Activity Summary

Receptors are located on the surface of all human cells to allow our cells to respond to their environment. Over 30% of prescription drugs act through particular receptors called GPCRs, however effective drugs without side effects are difficult to develop because we do not have a deep understanding of how GPCRs transmit complex signals. In this proposal we seek to resolve the atomic-level details of GPCR signalling to assist in the development of better drugs for a diverse range of diseases.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $1,071,370.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | cell signalling | nuclear magnetic resonance (NMR) spectroscopy | protein engineering | structure-based drug design

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