Understanding how cytomegaloviruses establish systemic infection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1140169

Funding Status
Closed

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Funded Activity Summary

Human cytomegalovirus (HCMV) infects most Australians, causes birth defects and harms transplant patients. Vaccines against it have worked poorly. HCMV spreads throughout the body and is never cleared. To control infection we must identify its key checkpoints. Using mouse CMV, we find that host dendritic cells, which normally defend against infections, are taken over and spread virus to new sites. The viral gene responsible is a potential target for intervention. We will define how it works.

Funded Activity Details

Start Date: 01-01-2019

End Date: 01-01-2022

Funding Scheme: Project Grants

Funding Amount: $668,144.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell migration | chemokine receptor | chronic infection | cytomegalovirus (CMV) infection | dendritic cell

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