Repurposing an Alzheimer’s trial drug to block relapse in cocaine addiction models

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1140050

Funding Status
Closed

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Funded Activity Summary

Repeated exposure to drugs of abuse, such as cocaine, alters the reward circuitry of the brain. Enduring changes in the connections between neurons underlie addiction-related behavioural patterns, drug craving and the propensity for relapse after drug withdrawal. The pre-clinical research in this proposal aims to test whether blocking the function of a particular brain protein in mice can prevent relapse in two different paradigms that model cocaine addiction in humans.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $1,050,601.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

addictive behaviours | animal model | plasticity | relapse prevention | synapse formation

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