The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1139865

Funding Status
Closed

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Funded Activity Summary

Why do some patients develop autoimmune diseases such as lupus where the immune system makes antibodies that attack its own body? To answer this, we plan to study a disease where a gene responsible for making antibodies is defective. Patients with mutations in the STK4 gene are unable to regulate the selection processes by which only the right cell is chosen to make antibodies. Understanding how STK4 works may help us unlock the mystery of what causes lupus.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $648,371.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoantibodies | autoimmunity | cell migration | germinal centre | immunodeficiency

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