Molecular Cloning and Expression of Cytokine Genes Related to Induction of Allograft Transplantation Tolerance in Rats

Funded Activity Summary

Cytokines are soluble proteins produced by leucocytes, and in many cases other cell types, which act as chemical communicators between cells, but not as effector molecules in their own right. Most of the cytokines are growth or differentiation factors and they generally act on cells within the haematopoietic system. In this grant application we will focus on the production of cytokines and antibodies to these cytokines, that are likely to be important in organ transplantation tolerance or organ rejection. We would like to synthesize these cytokines using molecular biological techniques. These biological materials will be used to treat animals and study their biological effect on transplanted graft survival. If the cytokine treatment does prolong graft survival, what is the mechanisms involved in the immune responses will be further studied. Our aim is to develop strategies that couold be applied to help pateints with organ transplants and receive most specific therapies.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $212,371.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Dermatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cardiac transplantation | Combined cytokine therapy | Cytokine cloning and expression | Cytokine profiles in graft survival | Immunosupression therapy | Manipulation of cytokine network | Mechanisms of cytokine therapy on graft prolongation | Rat cardiac allograft transplantation tolerance | Th1/Th2 T helper cells | Transplantation tolerance induction

Related Links