Chemokine and chemokine receptor regulation of T lymphocyte traffic to lymph nodes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/113906

Funding Status
Closed

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Funded Activity Summary

The movement of white blood cells from the bloodstream into the tissues is a key component of how we defend ourselves against infection and cancer, and also develop unwanted illnesses such as allergy. In particular, the migration of cells into lymph nodes is a critical step in the development of an efficient immune response. Surprisongly little is known about the control of this important cell trafficking process. In this research, the signals that control the movement of white blood cells are being studied, notably a specialised family of immunological hormones, known as chemokines. Our initial studies suggest that chemokines are indeed the factors which control the traffic of the most important cell type - T cells, into lymph nodes. This research will examine how the activity of specific chemokines controls the influx of particular groups of T cells and subsequently determines the characteristics of the overall immune response taking place in the lymph node.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $195,691.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Chemokine receptors | Chemokines | Lymph nodes | T lymphocytes | Trafficking | auto-immunity | immunisation | immunity | infectious diseases

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