Transforming Growth Factor Beta as a causal factor in human osteoarthritis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1138865

Funding Status
Closed

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Funded Activity Summary

Osteoarthritis (OA) is a common painful degenerative disease of the joints, which constitutes a major and growing public health problem, and for which there are no effective therapies. Our exciting recent research in the mouse has found that TGFb over-activity in the bone has a critical causal role in OA pathogenesis. Because TGFb silencing in bone could provide an entirely new way to slow the progression of OA, we propose to investigate this pathway in human OA.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $634,359.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone disease | bone marrow | cartilage damage | osteoarthritis | transforming growth factor beta (TGF-beta)

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