Interleukin 38: Uncoupling Innate Inflammation from Interferons in Lupus

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1138791

Funding Status
Closed

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Funded Activity Summary

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects 5 million patients worldwide, mostly young women. Grave multi-organ inflammation and substantial loss of life expectancy render SLE a critical unmet medical need. We found that the immune system protein interleukin 38 disables several signalling pathways essential for SLE progress. We will explore regulation and function of this protein in cells from healthy people and SLE patients and in models of the disease.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $1,048,669.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokine receptor | cytokines | inflammation | interferon-alpha (IFN-alpha) | systemic lupus erythematosus (SLE)

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