The in vivo biology of the novel TGF-b superfamily cytokine, MIC-1

Funded Activity Summary

Cytokines are hormone like messengers that mediate the interactions between cells. We have discovered a new cytokine that we have named macrophage inhibitory cytokine 1 (MIC-1). It belongs to a very important familty of proteins that are involved in wound healing, development and inflammation. Our data thus far suggest thatMIC-1 is an antiinflammatory factor that also involved in reproduction, especially in the health of the placenta. To determine the accuracy of these predictions we wish to use genetic techniques to delete this gene from a mouse. Study of this genetically modified mouse will give us a great deal of information on the most important roles of MIC-1.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $280,430.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

MIC-1, a novel TGF-b superfamily cytokine | atherosclerosis | chronic inflammatory diseases | embryo implantation and placental function | fetal growth and development | gene knockout | inflammation | monocytes or macrophages | rheumatoid arthritis | therapy with biopharmaceuticals

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