Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1138448

Funding Status
Closed

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Funded Activity Summary

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in the human genome, and drugs targeting these receptors account for 30% of marketed drugs. This project aims to determine high resolution structural information on how drugs bind and specifically interact with GPCRs, which will enable future development of selective and effective drugs.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $816,866.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | X-ray crystallography | drug discovery | muscarinic receptors | structural biology

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