Pericyte dysfunction limiting energy supply in Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1137776

Funding Status
Closed

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Funded Activity Summary

One possible cause of Alzheimer’s disease (AD) could be narrowing of small blood vessels (capillaries) within the brain, limiting blood flow and energy supply. Pericytes, a cell only on capillaries, maintain blood flow throughout the brain. I believe that pericytes may die in AD leading to an energy deficit and memory problems. I will test using human brains and animal models whether pericyte loss causes AD and how this is happening. Pericytes could provide a new therapy option for AD.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Targeted Calls

Funding Amount: $717,708.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | animal model | cerebral blood flow | neuropathology | neurovascular mechanism

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