Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1136065

Funding Status
Closed

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Funded Activity Summary

Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Development Grants

Funding Amount: $670,867.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

assisted reproductive technology (ART) | embryo | fertilisation | mitochondrial DNA (mtDNA) | oocyte

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