mRNA expression profiling of chronic lymphocytic leukaemia (CLL) cells from in vivo hypoxic microenvironmental niches; applications for in vitro research and clinical management.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1134083

Funding Status
Closed

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Funded Activity Summary

Chronic lymphocytic lymphoma (CLL) is the most frequently diagnosed leukaemia in adults and is still considered incurable. CLL cells proliferate in the lymph nodes and bone marrow; these are areas of the human body that are hypoxic when compared to blood. These hypoxic areas affect CLL cell survival, proliferation and treatment resistance. Changes that occur to CLL cells in these areas can be measured by gene expression profiling and modeled in a lab setting to identify targets for treatment.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Postgraduate Scholarships

Funding Amount: $124,676.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell culture | chronic lymphocytic leukaemia (CLL) | gene array | microenvironment | novel therapeutic agents

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