LINEs of Mutagenesis, Selection and Evolution in Ovarian Cancer and Chemoresistance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1130815

Funding Status
Closed

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Funded Activity Summary

L1 elements are powerful mutagens encoded within the human genome that becomes active in epithelial tumours. I will define the broad effects of L1 elements on the evolution of chemoresistance, focusing on ovarian cancer as a model system. Ovarian cancer is characterised by a poor 5 year survival rate of ~40% with most tumours developing resistance. Understanding the impacts of L1 on this evolution will inform the development and selection of more effective treatments for ovarian cancer.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2020

Funding Scheme: Career Development Fellowships

Funding Amount: $425,048.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genomics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

drug resistance | genomics | mutation analysis | ovarian cancer | transposons

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