Defining the mechanism of assembly of herpes simplex virus in the neuronal growth cone and its subsequent exit to epithelial cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1130512

Funding Status
Closed

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Funded Activity Summary

Herpes simplex virus (HSV) causes dormant infection of nerve cell bodies near the spine. It periodically reactivates to be transported along nerves to the skin where it causes oral, genital or neonatal herpes and mediates HIV superinfection. HSV assembles into its final form in the terminal part of the axon just prior to crossing into skin. Elucidating the mechanism of HSV assembly and exit will facilitate new strategies for antiviral agents and immune treatment for HSV and similar viruses.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $774,624.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Herpes simplex virus (HSV) | actin | epithelial cells | growth cone | viral proteins

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