Investigating deregulation of mitosis as a mechanism of tumourigenesis in MYCN-driven neuroblastoma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1129997

Funding Status
Closed

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Funded Activity Summary

Neuroblastoma chemotherapy often only works temporarily because a small number of tumour cells can resist drugs and eventually regrow as a new tumour. These resistant cells resemble the very first cells that turn into a cancer cell at tumour initiation. We have used single cell technology to uncover genetic markers of tumour initiating cells. In this project we will determine how these marker genes cause tumour initiation and develop therapies that target them in drug resistant neuroblastoma.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $372,298.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

combination therapy | genomic instability | mitosis | neuroblastoma | tumourigenesis

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