Real-time optical window imaging of AKT-FRET biosensor mice to maximise PI3K/AKT drug targeting within the hypoxic microenvironment of pancreatic cancer.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1129401

Funding Status
Closed

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Funded Activity Summary

Inefficient drug response in solid tumour tissue is often a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours with low oxygen levels known as hypoxia. Here, we will specifically target factors limiting efficient drug targeting in these areas to improve the encouraging anti-cancer profile of AKT inhibitors in pancreatic cancer.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $683,447.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biosensor | cancer | cancer cell biology | cancer metastasis | drug targeting

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