Computational reconstruction and validation of a gene regulatory network controlling differentiation of B cells to antibody-secreting plasma cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1128609

Funding Status
Closed

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Funded Activity Summary

Regulation of B cell differentiation, which occurs when our body responds to antigen infection is tightly controlled by a gene regulatory network. This project will be the first study to reconstruct a regulatory network for this process by using genome-wide expression and transcription factor binding data. The research finding from this study will elucidate the molecular mechanisms regulating this process and will shed new light on how this network is altered in lymphoma and myeloma.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $618,152.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinformatics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bioinformatics | cell differentiation | expression profiling | immunology | transcriptional regulation

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