RAGE and ACE2 shedding as therapeutic targets in diabetes and cardiovascular disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1127526

Funding Status
Closed

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Funded Activity Summary

We have previously demonstrated the pivotal role of two shed proteins, Receptor for Advanced Glycation End-products (RAGE) and Angiotensin Converting Enzyme Receptor 2 (ACE2) in heart disease and diabetic complications. In this project, we will use a novel technologies to modify shedding of these proteins from the cell surface and alter their ability to cause disease.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $748,447.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

diabetes mellitus | diabetic complications | diabetic vascular complications | receptor regulation | renin-angiotensin system (RAS)

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