NT-3 as an upstream and potentially master regulator promoting bone fracture healing

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1127396

Funding Status
Closed

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Funded Activity Summary

There is a strong clinical need for cost-effective treatments for delayed healing or non-union bone fractures. Our recent data suggest injury site-derived neurotrophin-3 (NT-3) may be an important overall regulator of bone repair by inducing key factors involved in fracture callus formation and remodelling. This project will address roles and mechanisms of endogenous NT-3 in bone repair and the likelihood of exogenous NT-3 protein in promoting bone healing in clinically relevant fracture models.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $712,857.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone cells | fracture healing | growth factor regulation | neurotrophic factors | novel therapeutic agents

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