Determining the mechanistic basis of the patterns of inverse drug susceptibility induced by two key drug resistance proteins of the malaria parasite.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1127338

Funding Status
Closed

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Funded Activity Summary

The inexhaustible capacity of many pathogens and cancers to develop resistance to new drugs is a serious threat to world health. Yet in acquiring resistance to one drug, many pathogens and cancer cells become hypersensitive to one or more other drugs. We seek to elucidate several of the molecular mechanisms underpinning this phenomenon in the malaria parasite. Insights gained from this work will contribute to the formulation of new therapeutic strategies that overcome or retard drug resistance.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $567,273.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasmodium falciparum | Xenopus oocytes | drug resistance | protein function | transporters

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