Novel approaches to control mast cell function in allergic inflammation.

Funding Activity

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Funded Activity Summary

Allergic disorders are a major health problem. Driven by mast cells, the underlying inflammation is exacerbated by the ‘?c family’ of cytokines acting on the surface of these cells. We aim to characterise the ‘mast cell-?c axis’ with the view to developing new therapies based on our ?c receptors blocking antibodies. This path of discovery-mechanism-translation seeks to recapitulate our previous success of taking a related antibody to Phase II clinical trials to treat patients with leukaemia.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $723,447.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antagonists | cell signalling | cytokine receptor | mast cells | monoclonal antibody