Physiologic and aberrant DNA recombination in B lymphocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1126682

Funding Status
Closed

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Funded Activity Summary

B cells produce antibody which is critical to fight infection. In order to perform this function, antibody genes must first be modified by immune enzymes. However, abnormal DNA attack by these enzymes outside of antibody genes can result in B cell cancer. How the immune system detects and destroys cancerous B cells is poorly understood. This research will provide insight into these processes, and in doing so will further our understanding of how B cell cancers develop and how they are destroyed.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $408,768.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunogenetics (incl. Genetic Immunology)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B cells | cytotoxic T lymphocytes (CTL) | lymphoma | recombination | somatic mutation

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