Identifying early molecular changes underlying familial Alzheimer’s disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1126422

Funding Status
Closed

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Funded Activity Summary

Analysis of our unique genetic model of inherited, familial Alzheimer’s disease (fAD) using advanced molecular, computational and behavioural techniques is revealing dramatic, early changes in brain function long before the disease would occur. We will expand our work to compare our first model with a model of the most common fAD mutation E280A “Paisa” from Columbia. Commonalities between the models will help us identify the initial stresses that cause Alzheimer’s disease.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $755,793.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Systems Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | brain ageing | mutation analysis | systems biology | zebrafish

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