Novel cell therapy for Hirschsprung Disease: from patient iPS cells to large animal trials

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1125805

Funding Status
Closed

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Funded Activity Summary

In Hirschsprung disease the lower bowel has no nerve cells. It does not function so it is surgically removed but quality of life is poor. A new idea is to replace the missing cells with new ones. Human infants are very large so we will use new stem cell technologies to create large numbers of cells. We will use polymer chemistry to devise a method of getting the cells into such a large organ as the bowel, and trial these on a model, the piglet, which closely resembles in size the human baby.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $1,011,764.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hirschsprung's disease | abnormal development | enteric nervous system | neural crest cell lineage | transplantation surgery

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