Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1125704

Funding Status
Closed

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Funded Activity Summary

Lyssaviruses such as rabies virus (RABV) and Australian bat lyssavirus cause rabies disease, which has the highest case-fatality rate of known infectious diseases, causing >60,000 human deaths/year. Critical to this is a protein produced by the virus that is important for both viral growth and evasion of the host's immune defences. This project aims to understand the molecular mechanisms underlying these processes, which may lead to new approaches to combat currently incurable viral diseases.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $900,995.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immune evasion | lyssavirus | nuclear magnetic resonance (NMR) spectroscopy | viral proteins | viral replication

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