How BANK1 pathway defects in B cells cause human lupus

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1125513

Funding Status
Closed

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Funded Activity Summary

Autoimmune diseases affect 1 in 20 Australians and are incurable. To find effective therapies, we need to understand the genes that cause disease in humans. We have sequenced the entire genome of patients with an autoimmune disease and found several patients carrry two mutations in genes important for activation of B cells and shown these mutations cause disease. We plan to understand how these genes prevent autoimmunity, and to identify the best treatment for patients with these mutations.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $1,316,839.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B cells | Toll-like receptors | autoimmunity initiation | lupus | lupus nephritis

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