Identification and targeting of a potent NK cell “checkpoint” in tumour immunity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1124788

Funding Status
Closed

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Funded Activity Summary

Cancer must evade detection by the immune system in order to develop. Natural Killer (NK) cells can detect and kill cancer cells. We have discovered a potent "checkpoint" in the NK cell activation pathway that desensitizes NK cells to growth factors and switches off their activation and killer function. When this checkpoint is inhibited, NK cells become hyper-activated and prevent most types of cancer metastasis in mice. Targeting this checkpoint in humans could revolutionise cancer therapy

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2020

Funding Scheme: Career Development Fellowships

Funding Amount: $470,144.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Tumour Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer immunotherapy | cytokine biology | natural killer cells | tumour immunology | tumour immunotherapy

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