Role of Erg in B-cell Acute Lymphoblastic Leukaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1122783

Funding Status
Closed

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Funded Activity Summary

Acute lymphoblastic leukaemia (ALL) is a lethal blood cancer for which current treatments are suboptimal. Over-expression of the ERG gene has been associated with the poor prognosis B cell ALL called Ph+ B-ALL. We have recently shown that loss of Erg prevents disease development in disease models. We hypothesise that expression of ERG is a key driver of Ph+ B-ALL and propose to define this role and identify new opportunities for development of specific novel therapeutics.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $749,034.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

haematological malignancy | leukaemia | molecular oncology | mouse models | transcription factor

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