An integrative structural biology approach to understanding the SAGA transcriptional master regulator implicated in cancer and development

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1122769

Funding Status
Closed

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Funded Activity Summary

Stringent control of gene expression ensures the harmonious life of all human cells. Loss of this control leads to development of a chaotic genome, characteristic of diseased states such as cancer. In this proposal, we aim at capturing and understanding the first key steps of the mechanism that, if dysfunctional, leads to aberrant gene expression. We will use cutting-edge structural bio-imaging to answer questions of fundamental importance to human health and pathologies.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $318,768.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer | electron microscopy | molecular modelling | structural biology | transcriptional regulation

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