TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1122073

Funding Status
Closed

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Funded Activity Summary

Scarring of organs such as the kidney, lung or liver is a common mechanism leading to organ failure and death. We postulate that a type of white blood cell (the macrophage) can transition into the cell type (the fibroblast) responsible for making the excess collagen that leads to this scarring. If proven, this will be a major advance in our understanding of organ fibrosis and may identify new therapeutic approaches to currently intractable diseases.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $683,739.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

glomerulosclerosis | kidney disease | macrophages | renal interstitial fibrosis | signalling pathways

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