Targeting myeloid cells to restrict gamma-herpesvirus spread

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1122070

Funding Status
Closed

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Funded Activity Summary

Gamma-herpesviruses infect most people and cause cancers. Vaccines to date have worked poorly. We have identified a key role for myeloid cells in infection that suggests a new approach. Interferons restrict infection in some myeloid cells. We will test whether inducing interferons can make all myeloid cells restrictive and reduce chronic infection. We will test then whether myeloid-restricting antibodies can recruit the same defences to provide a basis for vaccination.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $643,152.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Epstein-Barr virus (EBV) | dendritic cell | macrophages | vaccine biology | virus pathogenesis

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