The alpha5 GABA-A receptor: delineating an emerging therapeutic target

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1120947

Funding Status
Closed

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Funded Activity Summary

GABA-A receptors mediate inhibitory synaptic transmission in the brain. Receptors containing ?5 subunits are therapeutic targets for many neurological disorders. We aim to characterise the functional properties of the main ?5-containing isoforms using high-resolution imaging and whole-cell recording. Our goal is to understand which ?5-containing isoform should be preferentially targeted (and how) when seeking to treat the various disorders in which these receptors have been implicated.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $481,178.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gamma-aminobutyric acid (GABA) receptors | ligand-gated ion channels | molecular imaging | patch clamp | synapse

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