Characterising the pro-inflammatory role of IL-36γ/IL-36R in pathogen-induced exacerbations of asthma and COPD

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1120237

Funding Status
Closed

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Funded Activity Summary

Lung infections cause exacerbations in patients with asthma and COPD and these are difficult to treat and can be life-threatening. We have discovered that the cytokine pathway, IL-36?/IL-36R, is linked to the host response to bacterial and viral infections that induce exacerbations in these patients. Our studies will provide new insight into the role IL-36?/IL-36R in infection, disease exacerbation and determine the therapeutic benefit of blocking this pathway.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $738,768.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | asthma | chronic obstructive pulmonary disease (COPD) | cytokines | infection

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