The molecular basis of cytochrome P450 ligand binding: Towards predicting enzyme substrate selectivity and drug-drug interaction potential

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1120137

Funding Status
Closed

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Funded Activity Summary

Cytochrome P450 (CYP) enzymes play a pivotal role in the metabolism (i.e. chemical breakdown) of drugs, a process that is essential for their detoxification and elimination from the body. This project will combine advanced computational and experimental approaches to elucidate the molecular basis for the binding of drugs to CYP enzymes, which is crucial for the design of drugs with favourable metabolic properties and decreased propensity for harmful interactions with co-administered drugs.

Funded Activity Details

Start Date: 01-01-2017

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $558,447.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytochrome P450 | drug interactions | drug metabolism | enzyme kinetics | enzyme structure

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