The missing link: mGluR5 as a therapeutic target for cognitive decline in dementia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1111552

Funding Status
Closed

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Funded Activity Summary

Cognitive decline is a core feature of Alzheimer’s Disease (AD), yet there is no cure or treatment. Recent evidence suggests that a protein called mGluR5 could cause brain cells to lose function, leading to memory loss. This project will investigate whether disrupting mGluR5 function can improve cognition in mice with genetic AD. Memory will be assessed in mice using innovative touchscreen tests that closely mimic the tests used in humans.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Targeted Calls

Funding Amount: $563,622.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | dementia-related decline in memory | memory impairment | mouse models | pharmacology

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