Mechanisms of cortical and respiratory degenerations in Amyotrophic Lateral Sclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1111094

Funding Status
Closed

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Funded Activity Summary

This study will be the first to chronicle how and when motor neurons (MNs) in the brain and spinal cord degenerate before, during and after ALS symptoms in 2 different mouse models. The MNs studied control breathing muscles and are a key disease progression and mortality indicator in patients. I expect drastic shape and electrical abnormalities, providing information useful to clinicians about how and when brain and spinal cord MNs degenerate, uncovering new therapeutic targets and time-points.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Early Career Fellowships

Funding Amount: $333,900.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyotrophic lateral sclerosis | molecular basis of disease | motor cortex | patch clamp | pathogenic mechanisms

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