Targeting microRNA-200b in diabetic nephropathy using two novel delivery systems

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1110560

Funding Status
Closed

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Funded Activity Summary

Better treatments to prevent diabetic kidney disease are prioritized by government, commercial and philanthropic sectors. MicroRNA-based strategies limit kidney fibrosis in animal models of non-diabetic kidney disease. However, current delivery systems require optimization prior to human use. We have shown that microRNA-200b suppresses kidney fibrosis. We will study two delivery systems to deliver microRNA-200b to the kidney and to study its potential to prevent or limit diabetic kidney disease.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $314,644.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology and Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chronic renal failure | diabetic nephropathy | gene therapy | microrna | renal fibrosis

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