Myelin lipid breakdown affected by Apolipoprotein E genotype: implications for Alzheimer’s Disease pathogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1110400

Funding Status
Closed

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Funded Activity Summary

This project pieces together two important questions about Alzheimer’s Disease: (1) Why a naturally occurring variant of a gene called “APOE“ is the primary genetic risk for Alzheimer’s. (2) Why Alzheimer’s preferentially affects brain regions that lose a fatty substance called myelin, the electrical insulation of the brain. In doing so, we will understand more about what makes people more susceptible to Alzheimer’s and whether therapies to restore myelin could be effective against Alzheimer’s.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Targeted Calls

Funding Amount: $534,644.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Lipids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | apolipoprotein E | biochemistry | mass spectrometry | sphingolipids

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