How do TRIM21 and TRIM5α execute dual antiviral effector and signalling functions?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1110116

Funding Status
Closed

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Funded Activity Summary

We encounter millions of potential pathogens each day that must be detected and disarmed by the immune system. Recently, two antiviral proteins, present inside cells, were shown to both detect viruses, alerting neighbouring cells to the infection, and target the viruses for destruction. These two functions provide important protection against viral infection and this research aims to understand at a molecular level, how these dual antiviral functions are coordinated.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Early Career Fellowships

Funding Amount: $344,724.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biophysics | crystallography | protein-protein interaction | structural biology | viral immunity

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