Maternal immune activation and adolescent exposure to cannabis in rodents: Do two developmental “hits” lead to schizophrenia-like changes in brain and behaviour?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1109283

Funding Status
Closed

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Funded Activity Summary

The cause of schizophrenia most likely lies in early brain development due to either genetics or adverse environments. We will examine two successive environmental ‘hits’ in a rat model: infection during pregnancy followed by early adolescent cannabis use. We will track changes in the brain that occur in late adolescence and in young adults. We will also assess behaviour and brain function in adulthood to see if the animals exhibit patterns that mimic those that we see in schizophrenia.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $636,711.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | cannabis | event-related potentials | maternal infection | schizophrenia

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