Niche regulation of normal and malignant stem cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1108352

Funding Status
Closed

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Funded Activity Summary

Hematopoietic stem cells (HSC) reside in the bone marrow (BM) and make all the cells of the blood system. We study molecules in the BM regulating normal HSC to helping them survive chemotherapy. This means cancer patients should suffer less side-effects from their therapy. Some of these molecule also help leukaemia stem cells (LSC) resist chemotherapy. Inhibitors may a) reduce patient mortality caused by chemotherapy and b) sensitise LSC to chemotherapy enabling long-term cure.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Research Fellowships

Funding Amount: $622,655.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adhesion molecules | chemotherapy treatment effects | haematopoietic stem cell transplantation | haematopoietic stem cells | leukaemia

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