Directed evolution of AAV capsid variants for enhanced targeted genome editing in the human liver

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1108311

Funding Status
Closed

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Funded Activity Summary

Liver transplantation is often the only treatment option available for patients with severe liver disease, and is complicated by a shortage of donor organs and the need for life-long drug therapy to prevent rejection. Repair of a patient’s own liver by gene therapy is a promising alternative. This project focuses on developing the technology required to undertake precise correction of genetic spelling errors in diseased liver cells without the need to first remove them from the body.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $386,012.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene and Molecular Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adeno-associated virus | gene targeting | gene transfer | molecular evolution | recombination

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