L1 retrotransposition: the missing link between genetics and environmental factors in Parkinson's disease ?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1108258

Funding Status
Closed

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Funded Activity Summary

The study proposed here focuses on understanding the role of specific mobile DNA sequences in the interaction between environmental and genetic risk factors causing Parkinson’s disease (PD) leading to dementia. The project proposes identification of mobile DNA induced mutations in post-mortem human PD patient brain samples. The significance and mechanisms of mobile DNA induced mutations will be then tested in a PD mouse model.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2020

Funding Scheme: Targeted Calls

Funding Amount: $604,644.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Parkinson disease | dementia | dopamine | epigenetics | molecular basis of disease

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